منابع مشابه
Anti-glomerular basement membrane antibodies.
Basement membranes form an anatomic barrier that contains connective tissue. They are composed of type IV collagen, laminin and proteoglycans. Anti-basement membrane antibodies bind to the non-collagen site of the α3 chain of type IV collagen. A group of renal diseases, pulmonary diseases and perhaps others affecting different organs have long been associated with the presence of antibodies dir...
متن کاملAnti-Glomerular Basement Membrane Disease.
Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies targeting a well characterized autoantigen expressed in the basement membranes of these organs, although the inciting events that induce the autoimm...
متن کاملAtypical anti-glomerular basement membrane disease.
BACKGROUND Anti-glomerular basement membrane (anti-GBM) disease classically presents with aggressive necrotizing and crescentic glomerulonephritis, often with pulmonary hemorrhage. The pathologic hallmark is linear staining of GBMs for deposited immunoglobulin G (IgG), usually accompanied by serum autoantibodies to the collagen IV alpha-3 constituents of GBMs. METHODS Renal pathology files we...
متن کاملRituximab in anti-glomerular basement membrane disease.
The role of rituximab has expanded beyond the treatment of non-Hodgkins lymphoma, to include successful management of rheumatoid arthritis, systemic lupus erythematosus, anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis and primary glomerulonephritis. Decrease incidence of side-effects or toxicity, coupled with clinical effectiveness, suggests that B-cell depleting agents may ...
متن کاملBovine Glomerular Basement Membrane
The collagenous domain of bovine glomerular basement membrane was excised in soluble form by limited pepsin digestion and characterized. The domain amounts to approximately 25% of the whole membrane by weight. The constituent polypeptides were studied using several electrophoresis systems and amino acid analysis. The electrophoresis systems used were a combination of agarose and polyacrylamide...
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ژورنال
عنوان ژورنال: Nephron
سال: 1991
ISSN: 1660-8151,2235-3186
DOI: 10.1159/000186424